1900
- The University opened a school of commerce, making it the fourth university in the nation to offer a four-year business degree.
- With a final price tag of over $8,000, construction on the President's House was completed.
1902
- Because of a possible smallpox epidemic, University leaders and local health officials required students living in the dormitory to stay on campus.
1903
- Joseph Williams earned the first advanced degree from the University, a Master of Arts in Social Sciences.
1904
- The University celebrated the 30th anniversary of its founding. Professor of Classics James E. Church edited a memorial volume for the event.
1906
- The name of the University officially changed from Nevada State University to the University of Nevada.
- A devastating earthquake destroyed large parts of San Francisco, California, including the printers responsible for the year’s Artemisia yearbook.
1907
- The University received a bronze statue of Comstock pioneer John W. Mackay created by Gutzon Borglum commissioned by Mackay’s family.
- The department of Physics began offering classes.
1908
- The Mackay family donated $1.5 million to support a new mining building and its equipment, landscaping for the Quad, and an athletic field and training house.
- The dedication of the Mackay School of Mines building took place in June.
- The Mackay Mineral Museum opened to showcase minerals, rocks, and fossils from Nevada and around the world.
1909
- The Mackay Athletic Field and Training Quarters opened.
1910
- The student newspaper, The Student Record, changed its name to The U. of N. Sagebrush.
- Audrey W. Ohmert and Dorothy F. Riechers received the first R. Herz Gold Medals, given to the graduating senior(s) achieving the highest undergraduate grade-point average.
1911
- A ceremony commemorated the completion of the Orr irrigation ditch dam and Manzanita Lake.
1912
- The Mackay family established a $150,000 endowment for the Mackay School of Mines.
- Students enrolled in the first summer session of the University.
1913
- Campus held the first Mackay Day celebration.
- Students placed and whitewashed thousands of rocks to form a 140 by 150 foot "N" overlooking the campus on Peavine Peak.
1914
- The administration of President Stubbs ended with his death on May 27th.
- Archer W. Hendrick assumed the presidency on September 14th. He was the University’s 4th president.
- The Smith-Lever Act invigorated the Cooperative Extension program, leading to the creation of the Agricultural Extension Division.
- The University Library (now Jones Center), designed by Frederick De Longchamps, completed construction.
1915
- The first graduates in Electrical Engineering earned their degrees.
1917
- The University purchased 213 acres to establish the University Farm.
- The administration of President Hendrick ended on September 1st with his resignation.
1918
- On September 1st, the University celebrated the inauguration of Walter Ernest Clark as its 5th president.
- The University ordered a quarantine to contain the spread of the flu pandemic. No one was allowed to go from or to the campus without permission.
1920
- Classes began in the newly formed School of Education.
- The University established a federal radio station on campus.
- The University of Nevada received accreditation from the National Association of American Colleges and Universities.
- The University held its first homecoming activities.
- The football team became the first from the mainland to play a game in Hawaii.
- President Clark initiated the "Book of the Oath", to be signed by each successive class as a pledge to service and high ideals.
1921
- The University established an Engineering Experiment Station.
- James "Rabbit" Bradshaw, a standout football player, became Nevada's first All-American.
- University enrollment surpassed 500 students for the first time.
1922
- Faculty member Laura Ambler matriculated the first Journalism department students to the University.
1923
- The "Wolf Pack" officially became the University’s mascot.
1924
- Samuel B. Doten published his History of the University of Nevada.
1927
- Thanks to funds donated by William A. Clark, Jr., the University completed construction of Memorial Library.
1928
- Wá∙šiw Tribe member Lloyd Barrington became the first Native American to graduate from the University with a Bachelor of Arts in Economics.
1929
- The Mackay School of Mines established the Nevada Bureau of Mines.